Purity 99% HPLC
RUO: Research Use Designation Only. Not for human or veterinary use.

5 Amino 1MQ (5-amino-1methylquiinolinium) is a short peptide inhibitor of cytosolic nicotinamide N-methyltransferase (NNMT.) The NNMT enzyme has been linked to obesity, diabetes and weight gain. By inhibiting/decreasing NNMT in animals, researchers have seen significant weight loss, decreased fat mass and fat cell size as well as lower plasma cholesterol and glucose. 5 Amino 1MQ is currently being researched as a potential treatment for obesity and diabetes.

5 Amino 1MQ presents itself as a molecular compound which has been researched as a way to treat obesity via appetite suppression. 5 Amino 1MQ stimulates an increase in (NAD+), an energy cofactor that is crucial for metabolism. Research in mice given 5 Amino 1MQ showed a 7% reduction in body mass over 10 days without any changes in food intake.

5 Amino 1MQ has also demonstrated neuroprotective and cognition support properties in research studies. It has been studied for its effects on increasing satellite cell proliferation, lowering cholesterol, inflammation reduction and decreasing neurodegeneration.

5 Amino 1MQ offers researchers a direct link to elevating cognition, enhancing weight loss and improving physical performance in studies.

Research also shows that inhibiting NNMT, in any way, such as using 5 Amino 1MQ, may enhance and speed muscle repair via the stimulation of stem cells. This may result in faster healing after injury and prevention of sarcopenia in aging populations.

5 Amino-1MQ Structure

CAS Number: 42464-96-0
Chemical Formula C₁₀H₁₁N₂
Molar Mass: 159.21 g/mol
PubChem CID: 950107


Notes: 5 Amino 1MQ is available in a powder format. Capsules can be used to facilitate the handling and use of the powder. 5 Amino-1MQ acts as an inhibitor of NNMT. This enzyme plays a role in both obesity and type 2 diabetes and has been shown to play a role in energy within cells. Research shows that inhibition of NNMT can lead to higher levels of GLUT4 which has been shown to improve insulin sensitivity in rats and enhance resistance to the development of type 2 diabetes.

5 Amino-1MQ has shown significant ability to control glucose in rats and may offer an enhanced insulin response to sugar load. This helps reduce fat storage and shifts the metabolism in subjects.

5 Amino - 1MQ has strong research showing that the compound has beneficial effects on weight reduction, resistance to diabetes and improved lipid profiles in animals. There is also evidence that shows NNMT inhibition via 5 Amino 1MQ may regulate muscle and nerve cell function and play a role in reducing muscle wasting. It is worth noting that the reduction of levels of NNMT have been linked to reduced aggression of some forms of cancer.

Stability and Bioavailability: 5 Amino – 1MQ exhibits good oral and subcutaneous bioavailability in mice.

5 Amino – 1MQ Insights and Referenced Citations:

• NNMT inhibition – Subjects who had a reduction in NNMT showed improved insulin resistance and normalized glucose tolerance. NNMT plays an important role in obesity and inhibition increases energy expenditure, reduces bodyweight and improves fasting blood glucose levels

Biomed Res Int. 2021 July 27;2021:9924314. doi: 10.1155/2021/9924314

• Treatment with 5 Amino 1MQ combined with low fat diet promoted drastic whole-body adiposity and weight loss in diet induced obese mice. 5 Amino 1MQ treatment offers promising therapeutic approach to address ever-increasing rates of global obesity-linked comorbidities

Scientific Reports 12, Article Number: 484 (2002) Dimet-Wiley, A.,Wu,Q.,Wiley, J.T. et al.

• Muscle Function – NNMT inhibitors increase strength and promote the regenerative capacity of aged muscle, offering a treatment for sarcopenia. NNMTi treatment (alone or with exercise) will be beneficial in treating sarcopenia and a wide range of age-related myopathies.
  Sci Rep. 2024 Jul 5;14 (1):15554 doi. 10.1038/s41598-024-66034-9.

Usage: 5 Amino – 1MQ is sold for in vitro testing and laboratory research purposes only. Pure Bio Labs offers select peptides for investigatory and research strategies. All peptides should be handled by licensed, qualified professionals.

Quality Assurance: Every Pure Bio Research Material undergoes rigorous testing to ensure purity, potency and consistency.